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You Won Science: An Orphan Black Podcast

A podcast about Orphan Black, molecular biology, the history of science and some of the social and political underpinnings of the show from BBC America. Liz Tracey is your host, and a real live scientist type.
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Apr 15, 2016

Orphan Black has been telling us we have to go back...so we're reviewing the science of Seasons 1 & 2: Neolutionism, stem cells, and more. This is the first of three parts, and we'll be releasing them while covering Season 4.

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Crib notes for Season 4:

Read about Donna Haraway, and Cosima Herter's essay about how Haraway's work influences Orphan Black

http://www.bbcamerica.com/shows/orphan-black/blog/2016/04/eat-medrink-me-and-the-trouble-with-cyborgsEat Me/Drink Me and the Trouble with Cyborgs


Find us at:

Twitter: @You_Won_Science

Facebook: facebook.com/youwonsciencepodcast

Gmail: youwonscience@gmail.com

www.youwonscience.com

Mar 1, 2016

We're talking about S1E3: How do you solve a problem like Dead Katja? What's the best approach for babysitting? And how hard is self-surgery post-rebar impalement?

Also, we'll give a brief history of fingerprints, and answer the question of whether clones would indeed have identical ones.

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Show Notes

The History of Fingerprints

Beavan, Colin. 2001. Fingerprints: The Origins of Crime Detection and the Murder Case that Launched Forensic Science. New York: Hyperion. (Book that emphasizes Faulds’ role, and really hates Galton.)

 

Galton.org: Victorian polymath: geographer, meteorologist, tropical explorer, founder of differential psychology, inventor of fingerprint identification, pioneer of statistical correlation and regression, convinced hereditarian, eugenicist, proto-geneticist, half-cousin of Charles Darwin and best-selling author. (Contains all of Galton’s work on fingerprinting, as well as scans of the Nature letters from Herschel, Faulds and Galton. Thinks Faulds was a nobody whiner.)

 

The forgotten pioneers of fingerprint science, G. S. Sodhi and Jasjeet Kaur, Current Science, 2005. (PDF) http://www.iisc.ernet.in/currsci/jan102005/185.pdf
(Tells the stories of Haque’s and Bose’s contributions to the fingerprint classification system commonly known as the Henry System.)

 

Adermatoglyphia: The Genetic Disorder Of People Born Without Fingerprints, Joseph Stromberg, smithsonian.com, January 14, 2014.

http://www.smithsonianmag.com/science-nature/adermatoglyphia-genetic-disorder-people-born-without-fingerprints-180949338/?no-ist

 

The Claim: Identical Twins Have Identical Fingerprints. By ANAHAD O'CONNORNOV. 2, 2004, The New York Times

http://www.nytimes.com/2004/11/02/health/the-claim-identical-twins-have-identical-fingerprints.html?_r=0

Wikipedia

Fingerprint

https://en.wikipedia.org/w/index.php?title=Fingerprint&oldid=704300924

The Sepoy Rebellion/Indian Rebellion of 1857

https://en.wikipedia.org/wiki/Indian_Rebellion_of_1857


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You can find us at:

Twitter: @You_Won_Science

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Email us at hey@youwonscience.com

Ask us questions! Tell us things!

Please consider leaving us a review at iTunes, and thanks for listening!

Jan 29, 2016

Episode 2 of our Spoiler Free Rewatch ramps up the drama, and brings Sarah Manning within striking distance of the answers she's been seeking. Little does she know, it just gets weirder from here.

 

 

Jan 27, 2016

Now that the Season 4 teasers have come out, it's time to rewatch Orphan Black until the April premiere! Join us for our Spoiler Free Episodes to tide you over until then. 

This episode covers Season 1, Episode 1: Natural Selection, or Welcome Home, Sarah Manning!

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Show Notes

Charles Darwin Online:

http://darwin-online.org.uk

On the Origin of Species By Means of Natural Selection, &c.: 

http://darwin-online.org.uk/EditorialIntroductions/Freeman_OntheOriginofSpecies.html

EvoWiki: Discussion of Darwin and Racism
http://evolutionwiki.org/wiki/Darwin_himself_was_racist

Wikipedia: Scientific Racism
http://en.wikipedia.org/wiki/Scientific Racism

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Jul 28, 2015

Waiting for the return of Orphan Black is hard. We want to help.

This is the first part of our survival series, offering shows to watch when you're not rewatching (Orphan Black.)

NOTE: Episode 10B will be the first in our Rewatch series, covering Season 1, Episode 1: Natural Selection.

Show Notes:

Wired: Is Sense8 Too Radical For Critics?

Dark Angel — Official FOX Trailer (2000)

https://www.youtube.com/watch?v=P8kkHMJyOYI

 

Utopia Trailer Channel 4 UK (2013)

https://www.youtube.com/watch?v=r3gxwIqqzB4

 

Sense8 Trailer — Netflix (2015)

https://www.youtube.com/watch?v=iKpKAlbJ7BQ

 

Mr Robot Trailer — USA

https://www.youtube.com/watch?v=Ug4fRXGyIak

 

Humans Trailer — AMC

https://www.youtube.com/watch?v=eb2RTxKnmn8

 

 

Jul 11, 2015

In which we deal with our sadness at the end of Season 3, discuss the etymology of "neolution", talk about what our plans for the off-season are (hint: biweekly episodes, a rewatch of the series and the science never stops) and give a few more candidates for Season 4 episode title sources.

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Things we mention in the episode:

Anti-Intellectualism in American Life : Richard Hofstadter

The Immortal Life of Henrietta Lacks : Rebecca Skloot

The Tuskegee Syphillis Experiment

 

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Say hello. Ask us things. Tell us things. 

youwonscience.com

Email: hey@youwonscience.com

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Thank you for listening.

Jun 20, 2015

In which we wonder about why John Sadler had to die, discuss how hard it was to watch S03E09, and then explain mosaicism, chimerism and why mothers always have their children close to their internal organs.

Also: Shout outs to Tatiana is Everyone and Science Vs. Hollywood.

Enjoy the finale!

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CSI Chimera Episode and Blaschko’s Lines:
http://genetics.thetech.org/ask/ask75

 

 

Chimeras, Mosaics and Other Fun Stuff:

http://genetics.thetech.org/genetic-categories/chimeras-mosaics-and-other-fun-stuff

 

 

Blood Group Chimerism In Human Multiple Births Is Not Rare:

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.149.9001&rep=rep1&type=pdf (PDF File)

“Pregnancy may thus establish a long-term, low-grade chimeric state in the human female.”

Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC40117/

 

Y-chromosome DNA Is Present in the Blood of Female Dogs Suggesting the Presence of Fetal Microchimerism:

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068114 (open access)

Tatiana is Everyone: An Orphan Black Podcast

Science Vs Hollywood

Twitter:@You_Won_Science

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Jun 13, 2015

In which we briefly consider why Cosima hates to be the patient and whether the next faction hails from Cambridge, MA, then give you a crash course in proteins, prions and biochemistry. There will not be a test, but there are some handouts if you want them:

Conspiracy Maps: Leda Clones & Castor Clones

 

Proteins and Prions: UCSF Medical Center

 

Prions: On The Trail of Killer Proteins

 

Wikipedia: Prion

 

Stanley Pruisner's Nobel Lecture on Prions

 

Also, if you have a suggestion for the source of next season's episode titles, let us know. The poll will be available on our website and Facebook Page on Monday June 15th.

http://www.youwonscience.com
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Jun 6, 2015

Episode 005 - Chekhov's Uterus

In which we review Season 3, Episode 7 Community of Dreadful Fear and Hate and use Chekhov's Gun as a somewhat strained device to link Donnie's menstrual flow monitoring, Cosima's relapse, Shay's (possibly triggering) smoothies, and why you don't want to check your urine for misfolded proteins.

Next episode: Misfolded Proteins and Prions, Oh My.

Links:

Learn more about histology and epithelium at:

http://www.histology-world.com/contents/contents.htm#epithelium 

More advanced information at:

http://medcell.med.yale.edu/histology/epithelia_lab.php

Excellent overview of endometriosis:

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072685/

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Jun 2, 2015

Episode 004: Paul is Dead Now, Miss Him, Etc.

Show Notes

This episode is brought to you by Mercury Retrograde. Drive one today!


In which we miss Paul, wonder aloud about clones and dominant handedness, and begin a longer conversation (to be picked up in the next non-episode episode) about proteins, prions and disease.

Alchemical symbols (as seen in The Island of Dr. Moreau and the Blue Period paintings of Rachel Duncan):

http://alchemicaldiagrams.blogspot.com/2011/10/alchemy-symbols-with-meanings.html

Genes and Handedness

http://www.geneticliteracyproject.org/2014/12/02/left-handedness-genes-and-a-matter-of-chance/

HOMEWORK!


If you’re interested in boning up before Episode 6 - Misfolded Proteins and Prions, Oh My! here is an article to start reading. It’s a good overview with introductory material.

Protein Misfolding and Neurodegenerative Diseases
http://www.nature.com/scitable/topicpage/protein-misfolding-and-degenerative-diseases-14434929

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You can find us at:

Website: http://youwonscience.com

Twitter: @You_Won_Science

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Subscribe on iTunes: http://apple.co/1Jg0LNS


Thanks for listening!

May 27, 2015

In which I recap how Dyad's Rachel got where she is, both morally and physically, look at whether it could really happen like that, her prognosis (fictional and otherwise) and some bonus related scientific history. 

(If you're not current with Orphan Black, you should go away and please come back so you don't hate me.)

You can subscribe in iTunes here if you'd like.

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Show Notes: Episode 003 – They Saved Rachel’s Brain?

Physics

Force Diagrams with Measurements used can be found at  http://www.youwonscience.com/2015/05/27/ep003_shownotes2/
Projectile Motion Equations:
http://www.physicsclassroom.com/class/vectors/Lesson-2/Horizontally-Launched-Projectiles-Problem-Solving

Projectile Motion Simulation (with bonus Buick and Michelangelo statue)
https://phet.colorado.edu/en/simulation/projectile-motion

Inelastic Collision Calculator:
http://hyperphysics.phy-astr.gsu.edu/hbase/inecol2.html

Transorbital Intracranial Injuries:

Transorbital penetrating Brain Injury images
http://radiopaedia.org/cases/transorbital-penetrating-brain-injury
S Matsumoto, K Hasuo, A Mizushima, F Mihara, M Fukui, T Shirouzu, and K Masuda
Intracranial penetrating injuries via the optic canal.
Am J Neuroradiol 1998 19: 1163-5

http://www.ajnr.org/content/19/6/1163.long
Daniel M. Bursick, Robert G. Selker.
Intracranial pencil injuries.
Surgical Neurology, Volume 16, Issue 6, December 1981
http://dx.doi.org/10.1016/0090-3019(81)90235-4.
(NOTE:Article is paywalled: boo.)
http://www.sciencedirect.com/science/article/pii/0090301981902354
Frontal Lobe: Functions and Injuries

http://en.wikipedia.org/wiki/Frontal_lobe
The Centre for Neuro Skills | Brain Injury | Frontal Lobes
http://www.neuroskills.com/brain-injury/frontal-lobes.php

Neuropsychology (For samples of graded naming tests)
http://www.slideshare.net/monipoli/neuropsychology-compiled-report
Phineas Gage

http://en.wikipedia.org/wiki/Phineas_Gage

Phineas Gage: Neuroscience's Most Famous Patient
http://www.smithsonianmag.com/history/phineas-gage-neurosciences-most-famous-patient-11390067/?no-ist

Isaac Newton Sticking Things in His Eye

http://www.lib.cam.ac.uk/exhibitions/Footprints_of_the_Lion/8Bodkin.html (from his notebook)

http://thegruesomeblog.com/2014/07/27/isaac-newton-his-eye-and-his-bodkin/ (if you want to see a bodkin)

 

http://www.baumanrarebooks.com/blog/the-story-behind-opticks-by-sir-isaac-newton/

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Email us with feedback, questions, corrections or  anything else that comes to mind at hey@youwonscience.com

Thank you for listening!

May 20, 2015

In which we introduce our approximately 90 second audio summary, discuss the many questions raised by the episode, the few answers given, speculate wildly and deal with how lesbians get over breakups.

(Spoilers, obvs. So if you haven't seen "Scarred By Many Past Frustrations" go away and come back when you have.)


Episode 3 out on Thursday: We Saved Rachel’s Brain! or Take Me to the Cyclops.

Follow us on Twitter:

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Please send comments, questions, ideas, feedback, jokes, and dating advice to hey@youwonscience.com.

Thank you, as always, for listening!

 

 

May 13, 2015

In which I briefly discuss the mythology of the Leda/Zeus family, then conjecture wildly about what I'm calling the Helen Hypothesis, using relevant sound clips.

Show Notes: Episode 1 Leda and the Swan(Man)

Bullfinch’s Mythology: Full Text:
http://www.sacred-texts.com/cla/bulf/


Theseus-Daedelus-Castor and Pollux:
http://www.sacred-texts.com/cla/bulf/bulf19.htm

The Trojan War:
http://www.sacred-texts.com/cla/bulf/bulf26.htm

Classical Source Material on Leda, Queen of Sparta
http://www.theoi.com/Heroine/Leda.html



Wikipedia:
Leda and the Swan: http://en.wikipedia.org/wiki/Leda_and_the_Swan

Castor and Pollux: http://en.wikipedia.org/wiki/Castor_and_Pollux


Size of the Human Genome:
http://www.ncbi.nlm.nih.gov/books/NBK21134/#A5276

Short Tandem Repeats and Familial Relationships:
http://www.cstl.nist.gov/strbase/pub_pres/OConnor_USCIS_interpretation%20of%20DNA.pdf
(This is a PDF of a PowerPoint presentation explaining how one assesses familial relationships via STR testing)

Also:
http://en.wikipedia.org/wiki/DNA_profiling#STR_analysis

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Follow us on Twitter: @You_Won_Science

Website: http://youwonscience.com

Email comments, questions, concerns, jokes, etc. to hey@youwonscience.com 

Thank you for listening!

 

May 10, 2015

In episode 0 of You Won Science: An Orphan Black Podcast, I introduce myself and tell you a bit about why I'll be hopping the already moving bandwagon to talk about Orphan Black.

The TL;DL version: I've been in a PhD program studying genetics and am pretty much the East Coast butch Cosima. I feel strongly that Orphan Black is not just great, smart entertainment, but an opportunity for people to discuss the larger issues in play, as well as learn more about molecular biology (i.e., it's a science gateway drug.)

New episodes Mondays and Thursdays during the season, then moving to weekly after the finale.

You can follow us at:

Twitter: @You_Won_Science
Facebook: facebook.com/YouWonScience

Questions/concerns/suggestions can be sent to us at hey@youwonscience.com.

Thanks for listening! 

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